HORDB

ID: hor003049
Uniprot ID: P0C0P5
Protein name: Neuropeptide S
Gene name: Nps
Organism: Bos taurus (Bovine)
Family: Neuropeptide S family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032230 positive regulation of synaptic transmission, GABAergic; GO:0045760 positive regulation of action potential; GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO CC: GO:0005576 extracellular region

Sequence: SFRNGVGTGMKKTSFRRAKS
Length: 20
Propeptide: MIGSLKFNFILFLLISTMHMFWCHPISSSKVPGKSDYFVILLNSCPTRMDRRVGLDFLKPILEKTLMKRSFRNGVGTGMKKTSFRRAKS
Signal peptide: MIGSLKFNFILFLLISTMHMFWC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-A7REE5-F1.pdb

hor003049_AF2.pdb

hor003049_ESM.pdb

Mass:	255461	Formula:	C94H159N33O27S
Absent amino acids:	CDEHILPQWY	Common amino acids:	GKRS
pI:	12.82	Basic residues:	6
Polar residues:	9	Hydrophobic residues:	4
Hydrophobicity:	-101	Boman Index:	-6641
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	19.5
Instability Index:	2406	Extinction Coefficient cystines:	0
Absorbance 280nm:	0